VEGF and other signalling pathways What are angiopoetins? Angiopoietins in vascular instability Explore the evidence Resources Product information: Vabysmo
A new angle in retinal diseases
Explore the role of the Ang–Tie pathway in retinal and choroidal vascular diseases.
What is new
A new angle in Retinal Diseases

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As part of Roche Israel's commitment to ophthalmology, we have gathered here a variety of educational resources and materials for your use.

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Welcome to Eye On Angiopoietins

Discover how angiopoietins regulate vascular stability under normal conditions and drive vascular instability in retinal and choroidal vascular diseases.

Watch Ang–Tie Signalling: The Animated Journey
Discover how signalling pathways beyond VEGF contribute to the pathogenesis of DME, nAMD, and RVO.
Optimising outcomes Signalling pathways
Explore the key players in the Ang–Tie pathway and journey through the milestone events in their discovery.
The key players Discovery timeline
Discover how elevated Ang-2 and VEGF drive vascular instability, characterised by vascular leakage, inflammation, and neovascularisation.
Vascular instability Downstream effects
Review the data indicating the role of Ang-2 in driving vascular instability.
Clinical relevance Preclinical evidence
Access additional resources of interest to continue your understanding of the Ang–Tie pathway.
Expert prespective Downloads

Ang, angiopoietin; DME, diabetic macular edema; nAMD, neovascular age-related macular degeneration; RVO, retinal vein occlusion; Tie, tyrosine kinase with immunoglobulin-like domains; VEGF, vascular endothelial growth factor. 

Explore how factors other than VEGF are involved in the pathogenesis of DME, nAMD, and RVO…
VEGF and other signalling pathways What are angiopoetins? Angiopoietins in vascular instability Explore the evidence Resources Product information: Vabysmo
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