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Roche is committed to pioneering progress in precision medicine

Roche continuously develops new targeted treatment options based on agnostic biomarkers

*Multiple secondary sources used to cross validate information, including Trialtrove, clinicatrials.gov, EudraCT, ChiCTR; FDA approval timeline estimation based on Ph3 PCD + 8 months review; analysis based on current Phase 1/2, Phase 2 and Phase 3 trials with inclusion criteria requiring patient selection based on alterations to specific biomarkers; assumption made that all ongoing trials will lead to approval; “biomarker“ defined as any biological molecule found in blood or tissues that has either pronostic or predictive significance in cancer treatment, and for which the effectiveness of a therapy in a patient population defined by the detection of this molecule or molecular aberration is currently being tested or has already been approved.
CGP: comprehensive genomic profiling; FDA: U.S. Food and Drug Administration; HRD: homologous recombination deficiency;IHC: immunohistochemistry; MMR: mismatch repair; MSI-H: microsatellite instability-high; Ph: Phase; TMB: tumour mutational burden.

PrecisionONCOLOGY News, Aug 2022: https://www.genomeweb.com/companion-diagnostics/perspective-accessing-innovation-point-care-comprehensive-genomic-profiling