A closer look at vascular instability
Ang-1–Tie2 signalling promotes vascular stability, maintaining homeostasis, whereas Ang-2–Tie2 signalling drives vascular instability, characterised by vascular leakage, inflammation, and neovascularisation.1
The role of Ang-2 and VEGF in DME
See how Ang-2 drives vascular instability in retinal and choroidal vascular diseases in this animated video.
Download a visual summary of how Ang-1 and Ang-2 regulate vascular stability.
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Context-dependent effects of Ang-2 signalling
The effects of Ang-2 signalling on endothelial cells are context-dependent and mediated by several factors, including expression of receptors and modulators and levels of ligands. 1,2,8-13